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Deaths Among Adult Patients With Hypopituitarism: Hypocortisolism During Acute Stress, and De Novo Malignant Brain Tumors Contribute to an Increased Mortality

Burman, Pia (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Endocrinology, Skånes University Hospital ,Malmö/Lund, Sweden
Mattsson, A. F. (author)
Uppsala University,Pfizer Health AB, Endocrine Care, Sollentuna, Sweden,Department of Endocrinology, Diabetes, and Metabolism, University Hospital, Uppsala University, Uppsala, Sweden
Johannsson, Gudmundur, 1960 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Hoybye, C. (author)
Karolinska Institutet,Karolinska University Hospital, Sweden
Holmer, Helene (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Internal Medicine, Central Hospital, Kristianstad, Sweden
Dahlqvist, Peter (author)
Lund University,Lunds universitet,Berggrundsgeologi,Geologiska institutionen,Naturvetenskapliga fakulteten,Lithosphere and Biosphere Science,Department of Geology,Faculty of Science,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Berinder, K. (author)
Karolinska Institutet,Karolinska University Hospital, Sweden
Ekman, Björn (author)
Lund University,Lunds universitet,Socialmedicin och global hälsa,Forskargrupper vid Lunds universitet,Social Medicine and Global Health,Lund University Research Groups,Department of Endocrinology, Diabetes, and Metabolism, University Hospital, Uppsala University, Uppsala, Sweden,Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
Ekman, Bertil (author)
Linköpings universitet,Östergötlands Läns Landsting,Endokrinmedicinska kliniken,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
Erfurth, E M (author)
Department of Endocrinology, Skånes University Hospital Malmö, Malmö/Lund, Sweden
Svensson, Johan, 1964 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wahlberg, Jeanette, 1969- (author)
Linköpings universitet,Östergötlands Läns Landsting,Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinmedicinska kliniken,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
Karlsson, F. A. (author)
Dahlqvist, Per (author)
Umeå universitet,Medicin
Edén Engström, Britt (author)
Uppsala universitet,Endokrin diabetes och metabolism
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 (creator_code:org_t)
The Endocrine Society, 2013
2013
English.
In: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 98:4, s. 1466-1475
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Context: Patients with hypopituitarism have an increased standardized mortality rate. The basis for Objective: To investigate in detail the cause of death in a large cohort of patients with hypopituitarism Design and Methods: All-cause and cause-specific mortality in 1286 Swedish patients with Main Outcome Measures: Standardized mortality ratios (SMR) were calculated, with stratification for Results: An excess mortality was found, 120 deaths vs 84.3 expected, SMR 1.42 (95% confidence Conclusion: Two important causes of excess mortality were identified: first, adrenal crisis in response

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

hormone replacement therapy
pituitary-adenomas
premature mortality
gh
deficiency
long-term
radiotherapy
disease
risk
childhood
sweden
MEDICINE

Publication and Content Type

ref (subject category)
art (subject category)

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